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10.1038/nature07813 Nature 16 ChaudhariA.GuptaR.PatelS.VelingkaarN.KondratovR

Gomperts, E

B6 deficiency can cause irritability, fatigue, and difficulty concentrating, so maintaining adequate levels is important during treatment

Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66