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Its origin in gastric juice means it evolved specifically to survive in the harsh stomach environment

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Globally, I believe [no current data to support this] that large doses of oral B12 have been used to some good effect, although it's not possible to work out who will benefit unless you do the experiment, and for that, if it meets the criteria of a clinical study, it needs [certainly in the UK] to be appropriately designed and reviewed before the work starts, and the results should be presented afterwards

Monitoring for signs of dehydration like dark urine can help in maintaining proper hydration levels