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Unlike classical AKI models showing ROS-mediated pyruvate depletion (Legouis et al., 2022), our folate-injury model revealed elevated pyruvate, likely due to glycolytic surge overwhelming catabolism and MG-induced PDH/LDH inhibition

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In einem frhen Stadium kann sich dies in unspezifischen Beschwerden wie Mdigkeit und empfindlichem Zahnfleisch uern, weshalb der Zusammenhang mit einem Vitamin-C-Mangel in der Praxis nicht immer erkannt wird.(36) Darber hinaus kann eine geringe Vitamin-C-Zufuhr unabhngig vom Skorbut durch eine verminderte Aufnahme von Nicht-Hm-Eisen im Darm zur Entstehung einer Eisenmangelanmie beitragen.(37) Bestimmung des Vitamin-C-Status Die Ascorbatkonzentrationen im Plasma und in den Leukozyten gelten als valide Biomarker fr den Vitamin-C-Status.(13,17,38) Aufgrund der breiten Verfgbarkeit von Referenzdaten ist Plasma-Ascorbat der am hufigsten verwendete Messwert

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American Association for Thoracic Surgery Annual Meeting

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