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Furthermore, lactylation also regulates various enzyme activities or acts as downstream pathways of enzymes, including aldehyde dehydrogenase 1A3, lactate dehydrogenase A and B, and HDAC2 [126,127,128,129]

(Figure 1) When FZD and LRP5/6 detect Wnts, FZD loses its capacity to destroy -catenin, and the interaction of FZD with LRP5/6 and other receptor complexes inhibits the work of the destruction complex that would otherwise destroy -catenin, thus preventing -catenin from being degraded

Furthermore, there is an urgent need to develop innovative methods and elucidate mechanisms for selectively controlling ferroptosis in a way that does not harm healthy cells while treating autoimmune diseases

Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations