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Mild gastrointestinal effects appear to be the most common symptom-flatulence (which ceased after two weeks of NAC supplementation), headache, skin rash, diarrhea and nausea and vomiting of mild-moderate intensity.67,73,76,78,81) However, nausea and vomiting was also experienced in the placebo group of one particular trial, and was not evident in others.68) Other clinical trials have demonstrated no adverse effects, and NAC has shown to be very well tolerated in doses up to 8,000 mg/day in other areas of research.39,71,83) This suggests there may be scope for a higher dose of NAC to be investigated in OCD and OCRD patients who appear resistant to doses of 3,000 mg/day used in the discussed research