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For apical to basolateral (AB) and basolateral to apical (BA) permeability, compounds were added at 10 M concentration to the apical (A) side and basolateral (B) side, respectively, and the corresponding amount of permeation was determined by measuring compound concentration on the B or A side

Wear PPE including gloves, lab coat, and protective eyewear Handle compounds within approved laboratory workspaces Avoid inhalation, ingestion, or direct contact Dispose of materials according to institutional chemical waste procedures Maintain proper labeling and documentation for stored research compounds These practices support safe and controlled laboratory operation

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In cartilage biology research, investigators have observed that AOD9604 is associated with proteoglycan synthesis in chondrocyte models, suggesting potential activity in extracellular matrix maintenance