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A plaques result from the abnormal cleavage of amyloid precursor protein (APP) by betasecretase (BACE1) and gammasecretase, leading to the aggregation of A peptides, particularly A42, which is highly toxic to neurons (Hardy and Selkoe 2002)

Additionally, the GM also produces some neuroactive metabolites such as neurotransmitters or their precursors

The S protein is metastable when produced as a recombinant protein and prone to transform from its pre-fusion to a post-fusion conformation, shedding the S1 subunit (Fig

Seizures may be treated efficiently by life-long supplementation with pyridoxine or its biologically active form, pyridoxal phosphate, but even so patients may become intellectually disabled, for which there currently is no effective treatment