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As expected, TRPML1 knockout mice show a decrease in the thickness of myelinated axonal projections and optic nerve thickness, possibly caused by a decrease in blood supply (Grishchuk et al., 2016)

Moreover, CD5/ LNP-FAPCAR 2.2 led to an ~30% reduction in cytokine release compared with that of CD5/ LNP-FAPCAR 2.1 without altering lysis capacity (Fig