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In contrast, the E3 Ub-protein ligase NEDD4L degrades Dvl-2, thereby inhibiting Wnt / -catenin signaling and delaying renal fibrosis[51]

When comparing the responders from the CRWP group ( n = 12) to the non-responders in the same group ( n = 7), there was a significant difference in age with the responders being significantly older (4.23 0.22 years) than non-responders (3.48 0.18 years

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Lung tissue and sample preparation In each group, the left lungs of 6 mice were infused with 0.5 ml PBS three times for the harvest of bronchoalveolar lavage (BAL) fluid, while the left lung tissues of the other 6 mice were inflated with 10% neutral formaldehyde at positive pressure (25 cm H 2 O) (Glynos et al., 2018