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Furthermore, the presence of mutations at mitochondrial or nuclear DNA (mtDNA and nDNA, respectively) levels has been linked to personality disorders, behavioral disturbances, thought alterations, impulsivity, learning impairment, cognitive impairment, and dementia

The NF-B pathway is activated in inflammatory processes such as endothelial-to-mesenchymal transition in doxorubicin-induced cardiotoxicity and osteosarcoma cell growth, where it downregulates miR-506 to promote JAG1 expression (Xiao et al., 2020), mirroring patterns paradigms observed in GPS-related research