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It has not been established whether the clinical effects of tretinoin are mediated through activation of RARs, other mechanisms such as irritation, or both

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For example, sufotranferases catalyze the metabolism of phenolic drugs such as paracetamol, isoproterenol, salbutamol and dobutamine, and some steroid drugs such as budesonide and tibolone, and some opioid drugs such as morphine, hydromorphone, oxymorphone, butorphanol, levorphanol, nalorphine, and naltrexone (Kurogi et al., 2014)

Anti-arthritic activity of cell wall content of Lactobacillus plantarum in freunds adjuvant-induced arthritic rats: involvement of cellular inflammatory mediators and other biomarkers