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The overall construct predicts GHRH/GHS synergy in the human only in the presence of SRIF when the brain-pituitary nexus is intact, larger and more irregular GH pulses in women, and observed gender differences in feedback by GH and the single and paired actions of GHRH, GHS, and SRIF

For example, increased glycolytic metabolism promotes proliferation and cytotoxic capabilities of effector T cells but elicits poor persistence and lower differentiation of these cells into memory cells

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