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We detected higher oxidized states of Cys 170 of phosphofructokinase (PFK), Cys 247 of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Cys 379/80 of phosphoglycerate kinase (PGK) and Cys 49 and Cys 326 of pyruvate kinase M (PKM), which were all reported to interfere with either the primary or secondary function of these enzymes 32,33,34,35

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LD: Data curation, Investigation, Writing original draft

In conclusion, addressing the challenges and exploring future directions in harnessing microbial-derived metabolites for cancer immunity, immunotherapy, and chemotherapy requires interdisciplinary collaboration, technological innovation, and a deep commitment to advancing our understanding of the intricate relationships between the microbiome and cancer