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These included reductions in functional and cardiovascular age, greater exercise tolerance, and notably lower mortality: treated individuals had 28% fewer deaths overall, about half the cardiovascular mortality, and reduced incidence of heart failure & respiratory disease compared to controls

OS contributes to the pathogenesis of schizophrenia through its effect on neuronal excitability and mitochondrial signaling, factors which impart negative influences on neurons and ultimately promote the development of schizophrenia (161)

was funded by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship (101285/Z/13/Z)