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As reported in Table 1, among the analyzed tumor types, CRC shows the highest number of preclinical studies on DNA methylation ( N = 24), including 16 diagnostic and eight prognostic studies

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A.Borromeo-AustinC.HebrokM

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No sterile water must be discarded immediately after opening, while bacteriostatic water can last longer if handled aseptically

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pH-sensitive targets The tumor microenvironment and intracellular compartments like endosomes and lysosomes often exhibit a lower pH, which can be exploited by pH-sensitive nanocomposites for targeted drug release [136]

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