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Adv Parasitol 103:3173

In addition, it should be noted that individual effectors delivered by the Mtb ESX-1 secretion system may play independent immunoregulatory roles with different host targets, and thus, the mechanisms underlying ESX-1-dependent stimulation or evasion of the host cytosolic surveillance pathway both function during hostMtb interactions

The MYC oncogene the grand orchestrator of cancer growth and immune evasion

However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de novo serine synthesis pathway (SSP) enzymes or activation of oncogenes that drive enhanced serine synthesis