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For subcutaneous xenografts, BALB/c-nu/nu mice (male, 68 weeks, 18 1.5 g) were housed under controlled conditions (2224 C, 4060% humidity, 12-h light cycle) and randomly divided into subgroups

These findings suggest that DNA methylation changes in specific genes, such as ATXN1, in B cells may play a role in MS development (124)

GOT, glutamic-oxaloacetic transaminase

[1] [2] The American Diabetes Association (ADA) and the American College of Physicians (ACP) recommend metformin as the preferred initial pharmacologic agent for type 2 diabetes, alongside lifestyle modifications including diet and exercise