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With the presence of pro-inflammatory cytokines, such as IFN-, TNF-, INF-y, and IL-6, there is super stimulation of the action of IDO, which promotes an increase in the conversion of available tryptophan into kynurenine, thus causing greater activity of the kynurenine pathway and lower tryptophan bioavailability for the serotonin synthesis pathway (Raison et al

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The study found that the exosomal SP94-Lamp2bRRM, which targets HCC, aids in delivering small interfering RNA to improve sorafenib-induced ferroptosis by inhibiting the expression of GPX4 and DHODH

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