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found that hypoxia reduces NCOA4 expression in human macrophages, and siRNA transfection experiments showed that knocking down NCOA4 increases FtMt expression, protecting macrophages from RSL3-induced ferroptosis [20]

In the present study, we investigated the protective potential of N-acetylcysteine (NAC) against mercury toxicity, specifically focusing on mercury accumulation and the expression of genes associated with oxidative stress and inflammation in the lung tissue of rats

2022;283:114739 [Google Scholar] Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway