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In addition, optogenetic enhancement of the E/I ratio in the mouse neocortex provoked deficits in social behaviors relevant to autism 11

doi: 10.1093/oxfordjournals.aje.a115439

& Erusalimsky, J

Rarely, if the nodule is very large, the patient may also develop symptoms due to the enlarged thyroid gland such as difficulty with breathing or swallowing (as the enlarged gland may press on the food or wind pipes, which are located nearby)