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Results showed superiority of both levodopa dose reduction regimens with opicapone adjunct in terms of significant reductions of OFF-time and increases in ON-time vs the original 500 mg/day as well as significant increases in the minimum level of levodopa plasma concentrations and area under the curve (AUC) values

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Proteasomal processing results in complete proteolysis of the substrate, while deubiquitinating enzymes (DUBs) recycle ubiquitin molecules for subsequent rounds of degradation, ensuring the efficiency and sustainability of the pathway

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