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Features that may distinguish these patients from other classical EDS patients are the absence of atrophic scars, absence of collagen cauliflowers on ultrastructural examination of skin, and the recessive pattern of inheritance

Therefore, impaired renal function would likely impact both plasma and urine PK of pudexacianinium: compared with those without renal impairment, theoretically plasma concentration would be higher, urinary excretion would be lower, and urine concentration would be lower in participants with renal impairment