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Only free, unbound fractions can diffuse across the BBB, which drastically reduces the concentration of drug available for CNS penetration

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Baker C, Zhu V, Rosenbaum R

Essaghir, A

These characteristics correlate with an increased susceptibility to infections and allergies in the neonatal period ( Of the total content of amino acids (AAs) in human milk, 510% is present in free form