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Moreover, HIF expression has been observed in chondrocytes and osteoclasts, indicating its ubiquitous presence in synovial tissues (129)

The PPARGC1A (1XB7) was found to have hydrophobic, hydrogen, and unfavourable amino acid interactions with ALA 516, ARG 458, and GLY 489

Research Highlight Published: NAFLD Nature Reviews Gastroenterology & Hepatology volume 12 , page 123 (2015) Cite this article 4855 Accesses 34 Citations 11 Altmetric Metrics details Subjects New research shows that NASH is associated with increased intestinal permeability and indicates that an early phase of liver injury and inflammation contributes to this breach in the intestinal barrier

Strategies to address this include designing biocompatible dendrimers, adjusting surface charges, and applying chemical modifications to mitigate toxicity for clinical applications [201]