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144 Morevoer, Zhao et al

Downward J

Metabolic analysis revealed significant increases in the concentration of several metabolites known to be beneficial in the treatment of autoimmune diseases, including acetyl-CoA, ascorbic acid, citrate, butyryl-CoA, glutathione, glycoursodeoxycholic acid (GUDCA), and acetic acid, while significant decreases were observed in isoleucine and urea, among others (Supplementary Table 2)