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This is accompanied by loss of the glycocalyx and a 60% increase in permeability of the vascular endothelium, a change that is even more pronounced in patients who die as a result of sepsis, indirectly demonstrating that sepsis leads to the degradation of the glycocalyx and a compensatory increase in glycocalyx synthesis by endothelial cells (60)

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Insulin-like growth factor-I and insulin-like growth factor binding protein-3 cotreatment versus insulin-like growth factor-I alone in two brothers with growth hormone insensitivity syndrome: effects on insulin sensitivity, body composition and linear growth

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