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Also, it emphasized interspecies differences and the fact that the response in pathophysiologic stages is significantly different from normal physiologic stages

Topical methimazole, although not allowed in cosmetics, did not induce melanotoxicity or changes in thyroid functions [78, 98], and was proven to be a useful alternative treatment in some melasma cases [97]

Moreover, in the resistant interaction a significantly higher constitutive and pathogen-induced GST activity was observed