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Other adverse effects of hydrocodone include: Respiratory: severe respiratory depression, shortness of breath Cardiovascular: hypotension, bradycardia, peripheral edema Neurologic: Headache, chills, anxiety, sedation, insomnia, dizziness, drowsiness, fatigue Dermatologic: Pruritus, diaphoresis, rash Gastrointestinal: Vomiting, dyspepsia, gastroenteritis, abdominal pain Genitourinary: Urinary tract infection, urinary retention Otic: Tinnitus, sensorineural hearing loss Endocrine: Secondary adrenal insufficiency (17) Hydrocodone acts as an agonist and can cause sedation and respiratory depression when combined with other central nervous system depressants, so patients must not take it with those agents (53)

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Subjects commenced dosage at 2mg twice weekly and increased the dosage over a period of time until the desired results were reached

Under-dilution problems Too little water creates the opposite problem