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This structural effect on neural architecture is what distinguishes Dihexa from most nootropics, which act primarily through neurotransmitter modulation

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European Journal of Nutrition, 54 (2), 251-263

The misfolding and aggregation of mutant ataxin-3 protein contribute to the neuronal dysfunction and degeneration, primarily affecting the cerebellum, brainstem, and basal ganglia 93,94