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The binding of the RGD motifs to the V integrins expressed in tumor endothelial cells induces the protease-mediated cleavage of the iRGD peptide, producing two peptides, namely, CRGDR/K and GPDC

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The molecular weight and polydispersity index (PDI) of PEG-PLL were evaluated by gel permeation chromatographic (GPC) system consisting of Waters 2690D separations module and Waters 2410 refractive index detector