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FIGURE 2 3.1 Mitochondrial metabolism and bioenergetics in gluco- and lipotoxicity Dysregulated mitochondrial bioenergetics, metabolism, and OXPHOS are frequently observed in models of T2D

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In addition, accessory proteins such as COQ4, COQ8A/B, COQ9 and COQ10A/B are believed to facilitate enzyme complex assembly, substrate channeling or stabilization of the biosynthetic complex (commonly referred to as the CoQ synthome) but their precise molecular functions are still under investigation

To better understand the reliability of the reviewed studies, we conducted a methodological quality assessment based on key design features, including randomization, blinding, use of control groups, and sample size