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Inflammation reduction becomes visible in some cases

In macrophages, increased HO-1 expression shows the ability to convert mobilized M1 macrophages into alternately activated M2 macrophages with anti-inflammatory effects, which is essential for the wound healing phase [127]

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In addition, it is important to highlight that the regulation of intracellular antioxidant concentration is a double-edged sword: On the one hand, enhanced antioxidant activity represents an advantageous protection of the cells from ROS, whereas, on the other hand, the depletion of antioxidants represents an important strategy to sensitize cancer cells to chemotherapy (chemosensitization) (50)