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The induction of stress by therapy could affect tumor cells in different ways: including the induction of autophagy, cellular senescence, apoptosis, or necrosis, all of which are, in part, interconnected, and damages induced by therapyeither chemo- or radiotherapy could induce autophagy as a housekeeping process (Kanzawa et al., 2012)

These observations suggest that the consumption of cysteine and GSH in the presence of 3MP in cells expressing 3MST is due to the production of Cys-SSH, GSSH, GSSG and their polysulfide counterparts (Cys-SS n H, GSS n H, and GSS n G, n 2)

PubMed: (peer-reviewed) Pickart L, Margolina A