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In the pathology of OA, cellular iron overload can increase localized inflammatory mediators, contributing to OA development ( 2.2 Lipid peroxidation A disruption of cell membrane integrity, which can lead to cell death, represents one potential mechanism through which ferroptosis occurs

These genes promote acylation metabolism and mediate downstream oxidative stress and inflammatory responses by sensing copper ion stress and the outward transport and excretion of copper

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