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MetaboliteoftheMonth: #Succinate Succinate is a metabolic multitaskerthe only tricarboxylic acid (TCA) cycle metabolite that is also part of the electron transport chain. As a substrate for succinate dehydrogenase (Complex II), it links L Carnitine fumarate (CAS 90471 79 7) Glentham Life Sciences Carnitin Wikipedia L Carnitine fumarate 90471 79 7 wiki

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Interestingly, the IDH1 mutant glioma was the tumor that did not conform to this trend, suggesting that it has a distinct metabolic profile from the primary GBMs, but still harbors an astrocyte-like subpopulation that is selectively vulnerable to ferroptosis

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