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and dysregulated dopaminergic signaling and blunted reward response in the nucleus accumbens (Slcudean et al., 2025)

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Moreover, overexpression of mucin MUC13 exacerbates TJ dysfunction through the janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) and rho-associated coiled-coil containing protein kinase 2 (ROCK2)/mitogen-activated protein kinase (MAPK) signaling pathways, and IL-22 can activate these pathways [73]