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Alfafara, A., CG

A third, hitherto underappreciated dimension of JU-BAEC-01 success is the extraordinarily sophisticated arsenal of anti-phage defense systems that it possesses

Recently, quite a few of lncRNAs have been reported to serve as natural antisense transcripts (NATs), which transcribe from the opposite strands of their cognate sense genes and play important roles in various diseases ( Recently, increasing studies have documented oxidative stress to be a major driving mechanism in the pathogenesis of COPD ( Nqo1 has been reported to be a multifunctional antioxidant enzyme, which plays critical roles in protecting cells from oxidative damage through proteasomal degradation, xenobiotic detoxification, regulation of p53, superoxide scavenging and the maintenance of endogenous antioxidants ( Since NATs are capable of binding to their corresponding sense transcripts thereby regulating the expression of the latter ( The strengths of our study include determining the characterization of Nqo1-AS1, investigating the expression patterns of Nqo1-AS1 (or its human homologue) and Nqo1 in lung tissues of mice exposed to CS, mle-12 cells treated with CSE and PBMCs from patients with COPD, and examining the role of Nqo1-AS1 in the regulation of CS-induced oxidative stress