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Limited human evidence: Small studies or evidence primarily from deficiency or clinical populations that may not generalize

In tobacco BY-2 cells, sphinganine or dihydrosphingosine (d18:0, DHS) induce a calcium dependent PCD and trigger H 2 O 2 production via the activation of NADPH oxidase(s)

doi:10.1111/j.1365-2672.2008.03892.x Liang G, Liao X, Du G, Chen J (2009) A new strategy to enhance glutathione production by multiple H2O2 induced oxidative stresses in Candida utilis