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SIRT1, an NAD + -dependent class III histone deacetylase, regulates hepatic lipid metabolism through deacetylation of multiple transcription factors and metabolic enzymes, exerting a bidirectional effect on lipid homeostasis by inhibiting fat synthesis and promoting fatty acid oxidation

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Lucia Altucci, [email protected] These authors share last authorship This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers