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For data acquisition, we used VistaVision software (version 4.2.095, 64-bit, ISS) in time-tagged time-resolved (TTTR) file format, and images were obtained using a laser scanning module in which a three-axis DAC module (ISS) synchronized data acquisition and control over the galvo-scanning mirrors

An increase in glycolysis (thus lactate levels) has been detected in RA-FLS and is associated with inflammation (94, 95)

doi: 10.3390/pharmaceutics13111785 168 Bar-ZeevMLivneyYDAssarafYG

Clinically meaningful weight loss typically becomes apparent after 4 to 8 weeks of treatment, once therapeutic doses are reached and steady-state drug levels are achieved