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Depending on their forms and contents, most bioactive compounds can scavenge free radicals or function as antioxidants

Importantly, GSH itself does not spontaneously sequester hydroperoxides since the reaction kinetics are far too slow (30 M 1 s 1 ) (Berndt et al., 2 O 2 and lipid hydroperoxides or participate in covalent modification of protein cysteine thiols depends on various enzymes that specifically bind glutathione to catalyze redox reactions (Flohe, 2 O 2 and lipid hydroperoxide detoxification are enzymatically-mediated by glutathione peroxidase (Gpx) 1 and Gpx4

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