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Before this work, we knew the ER needed to stay oxidized to fold proteins correctly, but the machinery responsible for maintaining that balance was essentially a black box, says Gad

Zhifeng L, Yi J, Tianyuan Y, Hourong W, Yingqi Z, Di L et al

however, the pathway is present in gut bacteria [468]

Multidrug Resistance-associated Protein 1 (MRP1) and MRP2, of the ABC (ATP-Binding Cassette)-type subfamily C transporters, transport oxidized glutathione and glutathione S-conjugates when expressed in yeast 58,59 and might be involved in their transport from the cytosol into the vacuole in plants