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The increase in activity of AST and ALP in glucose fed-worms could be interpreted as a sign of aging, as a similar increase is observed in aged worms [38, 39], and could indicate that glucose exposure is accelerating aging in worms, as has been hypothesized previously [11, 49]

In fact, besides an overall identity of 79% that is somewhat lower than the average identity for other membrane transporters between human and mouse/rat isoforms, in ASCT2 there is a stretch of about 30 amino acids that is profoundly divergent in the different species (Pochini et al., 2014)

10.1007/s10529-010-0364-z Biotechnol

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma