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BV, MEL, and apamin alleviated LPS-triggered severe renal damage in mice by lowering cellular oxidation damage, inflammatory processes, and cell death

Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed

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Although the mutations like L452R, T478K have not been reported in previous VOC Alpha, Beta, and Gamma, these mutations gave VOC Delta a stronger transmission ability (with a reproduction number of 3.28, mean of 5) and immune escape ability than VOC Alpha, which made Delta variant quickly become a dominant variant and reduce the efficacy of approved vaccines ( Omicron In November 2021, B.1.1.529 appeared in many countries