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Sun-damaged skin

In the first step, glutamate and cysteine are ligated by -glutamylcysteine synthetase (also known as glutamatecysteine ligase, GCL) to form -glutamylcysteine, utilizing one molecule of ATP

Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF (2015) Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction