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Viral infections and chronic inflammation often create localized areas of hypoxia (low oxygen) in tissues, which activates the HIF-1 pathway, driving further inflammation and mast cell degranulation

Photobiomodulation ameliorates ovarian aging by alleviating oxidative stress and inflammation damage and improving mitochondrial function

The evidence relating to the potential pathways underlying the aforementioned prenatal factors is largely preclinical and implicates immune dysregulation, mitochondrial dysfunction, oxidative stress, gut microbiome alterations, and hormonal disruptions [15,16,17,18,19]