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As indicated in a recent report of the International Myeloma Working Group Mass Spectrometry Committee, although requiring assessment in a specialized laboratory, mass spectrometry can be effectively used to evaluate M-protein levels in treated patients and achieve high sensitivity in detecting residual serum M-protein

This timeline is built from the trial record primarily the Phase 2 monotherapy dose-finding study (Lau et al., 2021) and the REDEFINE Phase 3 combination trials (Aronne et al., 2025