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Chronic tendonitis (also called tendinopathy) is a long-term condition where a tendon the thick, fibrous cord that connects muscle to bone, becomes inflamed, irritated, or degenerated due to overuse or repetitive stress

This phenomenon is associated with increased blast counts, immunodeficiency, and increased risk of leukemic transformation (myeloid neoplasms) with poor prognosis

Formyl peptides have been shown to selectively activate phospholipase A2 (PLA 2 ) in neutrophils phosphorylated by p38 MAPK-activated kinase, and PLA 2 inhibitors block neutrophil chemotaxis toward formyl peptides but not toward CXCL8

doi: 10.1093/gerona/56.12.M775