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These patients exhibit lower numbers of retrieved oocytes, lower quality of oocytes, lower number of embryos and quality of embryos, and lower rates of blastocyst formation ( A key hypothesis we are studying here is that in endometriosis, a pro-oxidant microenvironment in the local vicinity of the follicle created by an unbalanced redox state detrimentally impacts the quality of oocytes, sperm, and embryos, hampering their cellular function, jeopardizing their viability, and that this is a fundamental underlying cause of diminished fertility with endometriosis

J Biol Chem 282(45):3321033217

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Several phase II clinical trials are presently being conducted