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Mitochondria are vital for cellular respiration to meet the energy demands of growing cells, and perturbations in genes regulating and maintaining both mitochondrial function and morphology can have devastating effects on overall brain development and thus may play a role in MCD (Figure 3) defective mitochondrial function has been observed in other disorders affecting cortical development ( post-mortem human embryonic tissue ( FIGURE 3 In the rare MCD and metabolic disorder Amish lethal microcephaly, cortical malformation occurs due to a mutation in solute carrier family 25 member 19 ( SLC25A19 )

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